The condition splenomegaly occurs when your spleen gets enlarged. It is also commonly termed as the enlarged spleen or spleen enlargement. The spleen constitutes a portion of your lymphatic system. It assists the immune system by accumulating white blood cells and aiding the creation of antibodies. However, the phytocannabinoid CBD can offer relief in this condition due to its analgesic, anti-inflammatory, and antitumoral properties.
What Is Splenomegaly?
As a critical portion of your lymphatic system, the spleen is an essential guardian organ that is relied on by you every day to keep the body free of viruses, infections and harmful pathogens of all types. An enlarged spleen also termed splenomegaly is a distinct alarming sign that the immune system is fighting hard to eliminate threats from the body but not succeeding as it can’t keep pace with high demand.
Normally, your spleen is nearly the size of your fist and can scarcely be detected by touch during a physical exam. However, when you’re ill or your lymphatic system is activated for another reason, your spleen inflamed and can increase dramatically in size.
Causes Of Splenomegaly
The causes of splenomegaly differ widely and range from infections, malignancy (cancers), congestion (elevated blood flow), inflammatory conditions, infiltration of the spleen from different diseases, and blood cell diseases.
Among the most common causes of splenomegaly comprise the following:
- Blood cancers (leukemia, lymphoma, myelofibrosis)
- Liver disease (chronic hepatitis C, cirrhosis from chronic hepatitis B, long-standing alcohol abuse, fatty liver)
- Infections (mononucleosis, malaria, bacterial endocarditis, Mycobacterium, AIDS, Leishmania)
- Gaucher disease (a lipid storage disease)
- Unusual blood flow and congestion (portal vein obstruction, splenic vein thrombosis, congestive heart failure)
- Idiopathic thrombocytopenic purpura (ITP)
- Inflammatory disease (rheumatoid arthritis, lupus)
- Blood cell disorders (thalassemia, sickle cell anemia, spherocytosis), and
- Polycythemia Vera
Symptoms Of Enlarged Spleen
The symptoms of an enlarged spleen may include:
- Pain or fullness in the top left abdomen that may extend to the left shoulder
- Feeling full without eating or after consuming just a small quantity by the enlarged spleen pressing against your stomach
- Easy bleeding
- Regular infections
- Hiccups due to irritation in the diaphragm
Consult your doctor immediately if you experience pain in your top left abdomen, particularly if it’s severe or the pain worsens when you inhale deeply.
How CBD Helps With Splenomegaly
CBD helps with the symptoms of splenomegaly like inflammation, pain, and infections due to its antibiotic, anti-inflammatory, analgesic and anti-tumoral properties.
Curbs Aches And Pains
The effects of CBD may be known to you while you are feeling sore. CBD attaches to CB2 receptors, limiting the production of the enzyme that splits down the neurotransmitter termed anandamide. Anandamide serves to block pain receptors. More anandamide leads to less pain.
Spleen inflammation often leads to discomfort. CB2 receptors are most dense in the spleen. The spleen manages the filtering of old blood cells to aid in enhancing the body’s immunity. The spleen also contributes to generating an anti-inflammatory response. This response increases when aided by CBD.
CBD also suppresses inflammatory response and subsequently relieve disease symptoms. This property of CBD is mediated through diverse pathways like induction of apoptosis in activated immune cells, suppression of chemokines and cytokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.
Aids To Stop Cancer
Generally, CBD gravitates to the concentrated CB2 receptors in the spleen, which houses the body’s immune system. There onwards, immune cells seek out and kill cancer cells. It has been shown that CBD has the capacity to directly kill cancer cells without passing through immune intermediaries. CBD hijacks the lipoxygenase pathway to directly limit tumor growth.
Conclusion On CBD In Splenomegaly
Occasionally the spleen gets damaged or enlarged due to side effects or disturbances in other organs, like the liver or different parts of the immune system. For instance, splenomegaly may develop as the liver gets congested and overworked (causing liver disease sometimes), working hard to throw toxins out of the body as fast as possible, but getting overwhelmed in the process. CBD aids to combat these conditions by reducing inflammation in the spleen and improving liver function.